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Laboratory of Chemical Biology of Natural Products

Graduate School of Bioagricultural Sciences, Nagoya University

Updated : 2026/7/27

2021

For detail, see the link

(Nagoya University

Faculty Profile)

Original Papers

O. Kutomi, R. Yamamoto, K. Hirose, K. Mizuno, Y. Nakagiri, H. Imai, A. Noga, J. M. Obbineni, N. Zimmermann, M. Nakajima, D. Shibata, M. Shibata, K. Shiba, M. Kita, H. Kigoshi, Y. Tanaka, Y. Yamasaki, Y. Asahina, C. Song, M. Nomura, M. Nomura, A. Nakajima, M. Nakachi, L. Yamada, S. Nakazawa, H. Sawada, K. Murata, K. Mitsuoka, T. Ishikawa, K. Wakabayashi, T. Kon, and K. Inaba

A dynein-associated photoreceptor protein prevents ciliary acclimation to blue light.

Sci. Adv. 7, eabf3621 (2021).

Y. Araki, Y. Hanaki, M. Kita, K. Hayakawa, K. Irie, Y. Nokura, A. Nakazaki, and T. Nishikawa

Total synthesis and biological evaluation of oscillatoxin D, E, and F.

Biosci. Biotech. Biochem. 85, 1371–1382 (2021).

[Link]

H. Hattori, T. Mori, T. Shibata, M. Kita, and T. Mitsunaga

6-Paradol acts as a potential anti-obesity vanilloid from Grains of Paradise.

Mol. Nutr. Food Res. 2100185 (2021).

D. H. Utomo, A. Fujieda, K. Tanaka, M, Takahashi, K. Futaki, K. Tanabe, H. Kigoshi, and M. Kita

The C29–C34 parts of antitumor macrolide aplyronine A serve as versatile actin-affinity tags.

Chem. Commun. 57, 10540–10543 (2021).

N. Hanif, D. Iswantini, Y. Hioki, A. Murni, M. Kita, and J. Tanaka

Flavokawains, plant-derived chalcones, inhibit differentiation of murine pre-adipocytes.

Chem. Lett. 51, 54–57 (2022).

[Link]

T. Tsuda, A. Arai, and M. Kita

Ligand-dissociation-type N,N-dimethylaminopyrene probes for in situ site-specific protein labeling.

Chem. Asian J. 17, e202200631 (2022).

S. N. N. Makiyah, M. Kita, I. Setyawati, and S. Tasminatun

Dioscorea alata L. improves diabetes through anti-hyperglycemia, anti-inflammation, ameliorate insulin resistance and mitochondrial dysfunction.

Indones. Biomed. J. 14, 365–375 (2022).

T. T. H. Le, Y. Hioki, P. Wonganan, T.-K.-D. Le, V.-K. Nguyen, M. Kita, and W. Chavasiri

A new neolignan and a new phenolic acid from the heartwood of Mansonia gagei JR Drumm.

Nat. Prod. Res. published online (2022).

D. H. Utomo and M. Kita

Binding mode of actin–aplyronine A–tubulin heterotrimeric complex revealed by molecular dynamics simulation

Bull. Chem. Soc. Jpn. 96, 120–126 (2023).

Y. Hioki, T. Sato, T. Iwao, J. Ikuma, A. Kawamura, T. Ohyoshi, Y. Tsunematsu, and M. Kita

Discovery of new cytotoxic aplaminone derivatives from the sea hare Aplysia kurodai and elucidation of their accumulation from local sea algae through the food chain.

Eur. J. Org. Chem. 26, e202300084 (2023).

M. Morishita, K. Hada, M. Kita, and T. Nishikawa

The asymmetric total synthesis and configuration confirmation of aplysiaenal and nhatrang A, truncated derivatives of aplysiatoxin and oscillatoxin.

J. Nat. Prod. 86, 1033–1041 (2023).

Y. Yano, R. Fukuoka, A. D. Maturana, S. D. Ohdachi, and M. Kita

Mammalian neurotoxins, Blarina paralytic peptides, cause hyperpolarization of human T-type Ca channel hCav3.2 activation.

J. Biol. Chem. 299, 105066 (2023).

F. Nakashima, W. Qi Loh, M. Wakabayashi, S. Shimomura, H. Hattori, M. Kita, A. Inoue, K. Uchida, and T. Shibata

Eriodictyol and thymonin act as GPR35 agonists.

Biosci. Biotechnol. Biochem. 87, 1514–1522 (2023).

M. Itakura, D. H. Utomo, and M. Kita

Development of actin dimerization inducers inspired by actin-depolymerizing macrolides.

Chem. Commun. 60, 4910–4913 (2024).

M. Nakatani, S. Ebihara, and M. Kita

Development of diazirine–alkyne tag for protein–ligand interaction analysis with photoaffinity labeling.

Chem. Lett. 53, upae142 (2024).

Y. Sun, A. Dakiiwa, M. Zhang, T. Shibata, and M. Kita

Inhibition of Lysosomal Cathepsin A and Neuraminidase 1 Interaction by Anti-obesity Cyclic Peptide.

Chem. Eur. J. 30, e202402049 (2024).

R. Fukuoka, Y. Yano, N. Hara, C. Sadamoto, A. D. Maturana, and M. Kita

Hyperpolarization Modulation of the T-type hCav3.2 Channel by Human Synenkephalin [1–53], a Shrew Neurotoxin Analogue without Paralytic Effects.

Angew. Chem. Int. Ed. 64, e202503891 (2025).

H. T. T. Le, Y. Hioki, T. L. Tuong, V. T. B. Hau, N. T. T. Thuy, W. Chavasiri, M. Kita, T. K. U. Tran, T.-H. Vo, T.-A.-T. Le

Secondary Metabolites of Mansonia gagei and Their Potential Anti-dengue Properties.

Chem. Biodivers. 22, e202500951 (2025).

S. Puspita, S. N. N. Makiyah, M. Kita, A. H. Ahkam

Potential of Bombyx mori Fibroin Peptide as An Inhibitor of BMP2 and TGFB1 in the Treatment of Pulp Tissue Damage.

Dental J. (Majalah Kedokteran Gigi) 58, 395–401 (2025).

M. Morishita, K. Hada, Y. Araki, K. Fukaya, D. Urabe, R. C. Yanagita, J. Maki, Y. Hanaki, M. Kita, K. Irie, T. Nishikawa

Synthesis of Unnatural Aplysiatoxin Analogs with High Affinity for Protein Kinase C.

Eur. J. Org. Chem. 28, e202500890 (2025).

N. Hara, C. Sadamoto, R. Fukuoka, Y. Yano, A. D. Maturana, M. Kita

In Silico Binding Mode Analysis of Blarina Paralytic Peptides with the Human T-type Ca Channel hCav3.2.

Toxins 17, 549 (2025).

H. Ando, A. Kanamori, M. Wakabayashi, F. Nakashima, H. Sei, H. Hattori, M. Kita, A. Inoue, A. Murakami, M. Akagawa, K. Uchida, Koji, T. Shibata

Structural and functional basis of G protein-coupled receptor 35.

Biochemistry 64, 4758–4767 (2025).

N. Hanif, J. S. Pakan, S. C. Lisias, W. B. Sael, N. F. Santosa, T. A. Tyas, M. M. Lemuel, K. Mohamad, S. Sa'diah, F. N. A. Dewi, E. T. Oluwabusola, Y. Tsunematsu, L. T. Tan, E. Chasanah, A. Murni, N. J. de Voogd, T. Jomori, M. Kita, M. Jaspars, J. Tanaka

Integrated biological and chemical investigation of papuan marine organisms for the discovery of potential cytotoxic marine natural products.

Nat. Prod. Res. in press (2025).

Y. Okura, C. Ando, N. Ogata, T. Ikeda, K. Kano, E. Mishiro-Sato, M. Kita, N. Miyoshi, K. Watanabe, K. Yoshinari, N. Shibata, M. Mori, S. Kobayashi, Y. Saito-Nakano, Y. Sumii, R. Shizu, T. Nozaki, Y. Tsunematsu

Chem-bio hybrid synthesis enables reengineering of natural product-based MetAP2 inhibitors for treating amoebiasis.

J. Am. Chem. Soc. 148, 7189–7201 (2026).

H. Sei, H. Ando, F. Nakashima, T. Takahara, M. Kita, K. Yamada, K. Uchida, T. Shibata

Missense mutations in Mg2+-coordinating residues of ACSL4 confer ferroptosis resistance in rat proximal tubular cells.

J. Biol. Chem. 302, 111232 (2026).

M. A. Asmaey, A. A. M. Elsoghiar, M. Kita, A. M. Moharram, A. I. Hasaballah, M. S. A. El-Gaby

Phytochemical profiling and larvicidal mechanisms of olive (Olea europaea L.) leaf extract against Culex pipiens: Antioxidant, enzymatic inhibition, and computational docking insights.

ChemistrySelect 11, e05097 (2026).

F. Nakashima, S. Shimomura, H. Hattori, M. Wakabayashi, W. Q. Loh, H. Ando, H. Sei, D. H. Utomo, M. Kita, A. Inoue, K. Uchida, T. Shibata

Identification and Characterization of Dietary Anthocyanidins as Agonists of G Protein-coupled Receptor 35.

FEBS J. 293, 1386–1399 (2026).

S. Ebihara, R. Takaiso, S. Kawaguchi, A. Oshima, M. Kita

Trisoxazole Macrolides Potentiate the Microtubule Assembly and Antimitotic Activities of Taxanes.

Angew. Chem. Int. Ed. 65, e202522954 (2026).

[press release]

D. Luthfiana, A. Dakiiwa, T. Shibata, M. Kita

Backbone N-Methylation Enhances Anti-Obesity Activity of Cyclic Peptide Stylissatin A.

Chem. Asian. J. 21, e70906 (2026).

Books and Reviews

M. Kita

Chemical biology studies on aplyronine A, a PPI-inducing antitumor macrolide from sea hare.

in New Tide of Natural Product Chemistry, Eds. H. Ishikawa and H. Takayama (Springer Nature), pp. 59–75 (2023).

M. A. Asmaey, M. Kita

Coffee Phytochemicals and Their Protective Roles in Hepatic and Renal Disorders: A Review.

Food & Function 16, 9282–9299 (2025).

M. Kita, H. Kigoshi

Aplyronines and mycalolides: Marine macrolides with diverse mechanisms for modulating cytoskeletal protein–protein interactions.

Bull. Chem. Soc. Jpn. 99, uoag053 (2026).

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