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天然物ケミカルバイオロジー研究室

Laboratory of Chemical Biology of Natural Products

Updated：2025/12/6

2021年~

全業績は名古屋大学教員データ →

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原著論文

O. Kutomi, R. Yamamoto, K. Hirose, K. Mizuno, Y. Nakagiri, H. Imai, A. Noga, J. M. Obbineni, N. Zimmermann, M. Nakajima, D. Shibata, M. Shibata, K. Shiba, M. Kita, H. Kigoshi, Y. Tanaka, Y. Yamasaki, Y. Asahina, C. Song, M. Nomura, M. Nomura, A. Nakajima, M. Nakachi, L. Yamada, S. Nakazawa, H. Sawada, K. Murata, K. Mitsuoka, T. Ishikawa, K. Wakabayashi, T. Kon, and K. Inaba

A dynein-associated photoreceptor protein prevents ciliary acclimation to blue light.

Sci. Adv. 7, eabf3621 (2021).

Y. Araki, Y. Hanaki, M. Kita, K. Hayakawa, K. Irie, Y. Nokura, A. Nakazaki, and T. Nishikawa

Total synthesis and biological evaluation of oscillatoxin D, E, and F.

Biosci. Biotech. Biochem. 85, 1371–1382 (2021).

[Link]

H. Hattori, T. Mori, T. Shibata, M. Kita, and T. Mitsunaga

6-Paradol acts as a potential anti-obesity vanilloid from Grains of Paradise.

Mol. Nutr. Food Res. 2100185 (2021).

D. H. Utomo, A. Fujieda, K. Tanaka, M, Takahashi, K. Futaki, K. Tanabe, H. Kigoshi, and M. Kita

The C29–C34 parts of antitumor macrolide aplyronine A serve as versatile actin-affinity tags.

Chem. Commun. 57, 10540–10543 (2021).

N. Hanif, D. Iswantini, Y. Hioki, A. Murni, M. Kita, and J. Tanaka

Flavokawains, plant-derived chalcones, inhibit differentiation of murine pre-adipocytes.

Chem. Lett. 51, 54–57 (2022).

T. Tsuda, A. Arai, and M. Kita

Ligand-dissociation-type N,N-dimethylaminopyrene probes for in situ site-specific protein labeling.

Chem. Asian J. 17, e202200631 (2022).

S. N. N. Makiyah, M. Kita, I. Setyawati, and S. Tasminatun

Dioscorea alata L. improves diabetes through anti-hyperglycemia, anti-inflammation, ameliorate insulin resistance and mitochondrial dysfunction.

Indones. Biomed. J. 14, 365–375 (2022).

T. T. H. Le, Y. Hioki, P. Wonganan, T.-K.-D. Le, V.-K. Nguyen, M. Kita, and W. Chavasiri

A new neolignan and a new phenolic acid from the heartwood of Mansonia gagei J.R. Drumm.

Nat. Prod. Res. published online (2022).

D. H. Utomo and M. Kita

Binding mode of actin–aplyronine A–tubulin heterotrimeric complex revealed by molecular dynamics simulation

Bull. Chem. Soc. Jpn. 96, 120–126 (2023).

Y. Hioki, T. Sato, T. Iwao, J. Ikuma, A. Kawamura, T. Ohyoshi, Y. Tsunematsu, and M. Kita

Discovery of new cytotoxic aplaminone derivatives from the sea hare Aplysia kurodai and elucidation of their accumulation from local sea algae through the food chain.

Eur. J. Org. Chem. 26, e202300084 (2023).

M. Morishita, K. Hada, M. Kita, and T. Nishikawa

The asymmetric total synthesis and configuration confirmation of aplysiaenal and nhatrang A, truncated derivatives of aplysiatoxin and oscillatoxin.

J. Nat. Prod. 86, 1033–1041 (2023).

Y. Yano, R. Fukuoka, A. D. Maturana, S. D. Ohdachi, and M. Kita

Mammalian neurotoxins, Blarina paralytic peptides, cause hyperpolarization of human T-type Ca channel hCav3.2 activation.

J. Biol. Chem. 299, 105066 (2023).

F. Nakashima, W. Qi Loh, M. Wakabayashi, S. Shimomura, H. Hattori, M. Kita, A. Inoue, K. Uchida, and T. Shibata

Eriodictyol and thymonin act as GPR35 agonists.

Biosci. Biotechnol. Biochem. 87, 1514–1522 (2023).

M. Itakura, D. H. Utomo, and M. Kita

Development of actin dimerization inducers inspired by actin-depolymerizing macrolides.

Chem. Commun. 60, 4910–4913 (2024).

M. Nakatani, S. Ebihara, and M. Kita

Development of diazirine–alkyne tag for protein–ligand interaction analysis with photoaffinity labeling.

Chem. Lett. 53, upae142 (2024).

Y. Sun, A. Dakiiwa, M. Zhang, T. Shibata, and M. Kita

Inhibition of Lysosomal Cathepsin A and Neuraminidase 1 Interaction by Anti-obesity Cyclic Peptide.

Chem. Eur. J. 30, e202402049 (2024).

R. Fukuoka, Y. Yano, N. Hara, C. Sadamoto, A. D. Maturana, and M. Kita

Hyperpolarization Modulation of the T-type hCav3.2 Channel by Human Synenkephalin [1–53], a Shrew Neurotoxin Analogue without Paralytic Effects.

Angew. Chem. Int. Ed. 64, e202503891 (2025).

[press release]

H. T. T. Le, Y. Hioki, T. L. Tuong, V. T. B. Hau, N. T. T. Thuy, W. Chavasiri, M. Kita, T. K. U. Tran, T.-H. Vo, T.-A.-T. Le

Secondary Metabolites of Mansonia gagei and Their Potential Anti-dengue Properties.

Chem. Biodivers. 22, e202500951 (2025).

S. Puspita, S. N. N. Makiyah, M. Kita, A. H. Ahkam

Potential of Bombyx mori Fibroin Peptide as An Inhibitor of BMP2 and TGFB1 in the Treatment of Pulp Tissue Damage. Dental J. (Majalah Kedokteran Gigi) 58, 395–401 (2025).

F. Nakashima, S. Shimomura, H. Hattori, M. Wakabayashi, W. Q. Loh, H. Ando, H. Sei, D. H. Utomo, M. Kita, A. Inoue, K. Uchida, T. Shibata

Identification and Characterization of Dietary Anthocyanidins as Agonists of G Protein-coupled Receptor 35.

FEBS J. in press (2025).

M. Morishita, K. Hada, Y. Araki, K. Fukaya, D. Urabe, R. C. Yanagita, J. Maki, Y. Hanaki, M. Kita, K. Irie, T. Nishikawa

Synthesis of Unnatural Aplysiatoxin Analogs with High Affinity for Protein Kinase C.

Eur. J. Org. Chem. 28, e202500890 (2025).

N. Hara, C. Sadamoto, R. Fukuoka, Y. Yano, A. D. Maturana, M. Kita

In Silico Binding Mode Analysis of Blarina Paralytic Peptides with the Human T-type Ca Channel hCav3.2.M. Morishita, Toxins 17, 549 (2025).

H. Ando, A. Kanamori, M. Wakabayashi, F. Nakashima, H. Sei, H. Hattori, M. Kita, A. Inoue, A. Murakami, M. Akagawa, K. Uchida, Koji, T. Shibata

Structural and functional basis of G protein-coupled receptor 35.

Biochemistry in press (2025).

著書

M. Kita

Chemical biology studies on aplyronine A, a PPI-inducing antitumor macrolide from sea hare.

in New Tide of Natural Product Chemistry, Eds. H. Ishikawa and H. Takayama (Springer Nature), pp. 59–75 (2023).

北将樹、木越英夫

アメフラシから得られた抗腫瘍性物質.

in 海洋天然物化学（化学の要点シリーズ43）日本化学会編、共立出版 pp. 111–119 (2023).

総説・解説記事

北将樹

魅力ある動物毒を追いかけて.

化学と工業 76 (8), 548–549 (2023).

M. A. Asmaey, M. Kita

Coffee Phytochemicals and Their Protective Roles in Hepatic and Renal Disorders: A Review.

Food & Function in press (2025).

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